Professionals in Healthcare

Understand the genomic contribution or likely causative factors of your client’s current health profile. Pathway driven genomics will assist practitioners in understanding personalized approaches to health.

You as practitioners can incorporate genomic information relating to lipid metabolism, blood levels of vitamins, detoxification pathways, mental health and physical activity to provide clients with a targeted approach to health and well-being.

MTHFR rs1801133, rs1801131

 

The Methylenetetrahydrofolate Reductase (MTHFR) gene encodes MTHFR protein. A distinct combination of two MTHFR gene polymorphisms C677T and A1298C result in the produce an enzyme with 70% reduced activity. Other combinations produce enzymes with different levels of enzyme efficiency. The methylation pathway has significant role in many bodily functions including DNA synthesis and repair, cell division, and cell growth.

APOE rs429358, rs7412

 

Apolipoprotein E (APOE) is responsible for the production, delivery, and utilization of cholesterol in the body. Variations in APOE function lead to variations in cholesterol levels in the blood as well as in other tissues. High blood cholesterol is a major risk factor for cardiovascular disease. It is for this reason that the APOE genotype or Lipid Metabolism Type is used as the main dietary hub.

GST-T1, M1, P1

 

The Glutathione-S-transferase enzymes detoxify many water soluble environmental toxins, including many solvents, polycyclic aromatic hydrocarbons, steroids, herbicides, fungicides, lipid peroxidases and heavy metals such as mercury, cadmium and lead. Decreased glutathione conjugation capacity may increase toxic burden and increase oxidative stress. Copy Number Variations in the GSTT1 and GSTM1 enzymes are associated with less effective detoxification of potential carcinogens may confer an increased susceptibility to some cancers. If either or both the GSTT1 or GSTM1 enzymes are ABSENT they are assigned a Null genotype. If either copy is present, it is termed PRESENT. The GSTP1 gene encodes for an enzyme, glutathione S-transferase P1 (GSTP1) located in brain tissue, skin tissue and lung tissue which is involved in Phase II detoxification of carcinogens, xenobiotics, steroids, heavy metals and products of oxidative stress. The GSTP1 rs1695 polymorphism produces a variant enzyme with lower activity and less capability of effective detoxification.

“Once we know what is going on inside you we can start figuring out how to handle it”

- Bert Sansaar, Physical therapist

“My primary role is to improve the quality of life for my clients through physical intervention. This is a process aimed to reduce pain and improve mobility for individuals from all walks of life. Since working with the smartDNA Genomic Wellness Test my methods have become much more holistic. I am able to evaluate and diagnose my clients needs, taking into account their pathway driven genomic information. Together, we are able to start a process of pain recovery and work towards a healthier future. My client feels empowered, and as their health professional so do I!”